Everybody's got a different way they prefer to interact with their computer. Some folks swear by the command prompt. Others like WYSIWYG but don't want to take their hands off the keyboard. Then there are the mouse aficionados, who would rather double-click their way through life. The next group, those who would prefer to just wave their hand to make things happen, will be interested in MouseWrangler.
This tool lets you use gestures—movements of the mouse—to initiate system events. Once it's installed, you just hold down the right mouse button and then move your mouse around the desktop. You can associate movement in various directions—up, down, left, right, and even diagonally—with particular commands. Start or stop apps, enter chunks of text, or just about anything else you want to do. Couple with with your own keyboard macro tool, and you can drive the whole system with the wave of your hand. You'll feel like like a Big Deal as Windows quakes before your awesome might. Or at least you'll get more work done.
MouseWrangler is a free Windows application.